Research Programs

Overview

ACCTA, Inc. participates in a variety of research activities, often in cooperation with our customers, independent laboratories, or other contract research organizations. Our expertise in analytical method development and problem-solving allows us to solve technical challenges more efficiently than other organizations who lack experience or a problem-solving attitude.

The programs described here have produced successful results, and we now offer related products and services. If you are interested in more details on any of these programs, or would like to discuss a new opportunity, please contact us.

Research Highlights

Integration of Chromatographic Peaks

Chromatographic integration is the process that generates analytical results from chromatography data. Yet despite the importance of this technique, there is no systematic information available on how to select from the various integration options (drop, valley, skim, etc.). Our research using PeakTrain software pointed us in the right direction. Following this initial effort, we created hundreds of actual chromatographic combinations by varying relative peak ratios and resolution. Analysis of the data allowed us to develop general rules for integration of poorly resolved peak pairs, and suggestions for dealing with more complex chromatograms. You can learn more about this research from either an on-site seminar or an on-line course.

Analytical Method: Creatine and Creatinine

We are often asked to develop analytical methods to support a particular project or program. When asked to find a method for creatine and creatinine, we were disappointed to see the quality of published methods - complicated mobile phases, slow equilibration, and long analysis times. Our method uses an easily prepared mobile phase (with no ion pairing agents), a commercially available column, and is complete in less than two minutes! You don't have to spend your time on method development. You can get the method from us, along with many other related support services. Click here for more information.

HPLC Stationary Phase Research: Perfluorophenyl phases

These unique phases can exhibit both normal and reversed phase LC behavior, in the same separation, depending on the mobile phase and analytes. Our research is focused on understanding the mechanism of retention, particularly for more polar analytes, and those with a charge. We are exploring unique mobile phase systems that offers more flexibility for controlling retention, yet are simple to prepare. As we develop a better understanding of the underlying retention mechanisms, our list of applications will increase quickly. Contact us for more information, or to discuss your particular application.