Selectivity in Analytical Chemistry

The most neglected aspect in analytical chromatographic methods over the years has been how specific analyte or analyte class selectivity can be enhanced. Most real world applications involving complex samples could be dramatically improved if some sort of selectivity enhancement could be employed. This course systematically surveys four strategies for improving selectivity, highlighting specific examples where selectivity enhancement has been successfully employed.

Students will learn about:

• General strategies for improving selectivity
• Detailed information on the many options available
• The most efficient ways to improve selectivity
• Real-world applications that use selectivity wisely

Outline

1. Improving selectivity through detection strategies
2. Enhancing selectivity through sample preparation
3. Selectivity changes using derivatization technologies
4. Changing chromatographic selectivity (stationary and mobile phase)

Course Length: one or two days