Webinar Topics

• How to get your system ready for analysis
• How do you know your system is ready for analysis?
• The one most important parameter that you should always monitor
• Tips for extending your column's lifetime
• Best practices for both isocratic and gradient elution
• Common problems in data analysis

• Newer users
• Experienced users who want to assume a larger role in laboratory operations
• Supervisory staff

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HPLC Basics for Quality Staff and Auditors

Chromatographic data are used to answer critical questions - drug purity, content uniformity, impurity levels, etc. The language and practices of HPLC are complex and not always completely understood, even by users. Review of these data sets often is performed by auditors who do not have a laboratory background in these techniques and discussing the results with chromatographers can be difficult if you don't speak the "language of chromatography."

This presentation provides an introduction to HPLC with an emphasis on understanding the language and practices that an auditor needs to properly review chromatographic data. Topics will include a discussion of the components and how their failure can affect results, a review of common chromatographic problems, and suggestions for dealing with problems.

Topics:

• Brief introduction to chromatography and HPLC
• Brief description of HPLC components and their associated problems
• The language of chromatography
• Checklist for reviewing data
• Basic troubleshooting - what happens when a component fails
• Investigating problem data
• Real-world examples

Who should attend?

This seminar is for auditors, other Quality staff, and supervisors who do not have a technical background in chromatography, but must review and approve chromatographic data.

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Reducing Integration Errors In Chromatography - Part 1: When Peaks Are Approximately the Same Size

Integration of chromatographic peaks is a critical step in the generation of chromatographic data. Errors in integration will result in a corresponding error in calculated results. Unfortunately, most analysts have little or no training in the proper procedures for peak integration. We will first discuss, in general terms, how integrators work. Then, peak integration issues will be examined using sets of real chromatographic data to illustrate when to use different integration strategies (drop, valley, etc.). We will discuss a variety of situations involving poorly resolved chromatographic peaks, when the peaks are about the same size.

Topics:

• Introduction to chromatographic integrators
  • How do they find the peaks?
• What does resolution mean when the peaks are not of equal size?
• What integration baseline options are available?
• Integration errors for each baseline option and recommendations for selecting the best option.
• Sources of integration errors
  • Why are the numbers wrong?
• Discussion - Questions and Answer

• All chromatographers can benefit from this presentation.
• Reviewers will also find the content to be useful.

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Reducing Integration Errors In Chromatography - Part 2: Impurity and Trace Analysis Situations

The measurement of small peaks is a particularly challenging analytical problem, especially if there is a large peak next to the small peak. This webinar will focus on the integration errors that can result from the use of the wrong integration method. The erros can be large (more than 100%). Attend this seminar to learn the best way to integrate small peaks.

Topics:

• What integration baseline options are available?
• Review of results when peaks are of approximately equal size.
• Integration errors for each baseline option and recommendations for selecting the best option.
• Sources of integration errors for small peaks.
• More complex topics
  • Tailing, unresolved peaks
• Discussion - Questions and Answers

• Chromatographers who use trace analysis or impurity methods will find this information to be useful.
• Reviewers will also benefit from the content.

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Secrets of the ChemStation - Part 1: Understanding the Interface
(Both LC and GC versions are available)

Just learning the ChemStation? Confused by the new interface (B.02 and later)? We will discuss the general organization of all versions of the software and show you how to use the features of the newest versions (up to B.04.03).

Topics:

• ChemStation Views and general operation
• Using Preferences in the newer versions
• Understanding Diagnosis in the LC versions
• Using Lab Advisor in the newer versions
• Editing methods

Note: This seminar will use examples from both the LC and GC ChemStation. Please register for the correct version. This seminar does not discuss the current GC-MS interface.

Who should attend?

• New users of the ChemStation software.
• Existing users who have upgraded to a newer version.
• Anyone struggling with understanding how to use the software.

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Secrets of the ChemStation - Part 2: Integrating and Calibrating

Generating reliable chromatographic information requires that all peaks be integrated properly. The ChemStation has powerful and flexible integration capabilities, if you know how to use them. The ChemStation can also perform many calibration calculations for you, if you know how to set up and configure the system. (It is easy, but not always intuitive.) We will help you with both issues.

Topics:

• Using the enhanced integrator in all ChemStation versions.
• Understanding the new integration options in the newer versions (B.01 and later)
• Setting up calibration tables
• Configuring and using your calibration information

Who should attend?

• All ChemStation users who currently use manual integration because they are not able to get the ChemStation to integrate properly.
• Users who generate complex chromatograms.
• Any user who wants to learn more about integration capabilities.
• Anyone who wants to have the ChemStation do the calibration calculations. After this seminar, you will not need to use Excel to perform these calculations.

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Secrets of the ChemStation - Part 3: Sequences and Automation

Autosamplers allow us to automate the injection process, but you will only realize a significant improvement in efficiency if you can also automate the data analysis and reporting activities. The ChemStation offers many options for injection and calibration, if you design your sequence properly. We will show you how.

Topics:

• Setting up simple sequences
• Understanding automation and reprocessing concepts
• Batch Review and Reprocessing
• How do the different ChemStation versions organize sequence injections?
• Reporting options

Who should attend?

• ChemStation users who want to increase their efficiency by more effectively using sequences.
• Anyone who wants to learn how to review sequence data and reprocess data, without re-injecting.
• Operators who have upgraded to a newer version of the software and don't understand how to use the sequence data in the new version.

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Instructor